"Unfortunately, all the Windows NT family (including Vista) still have the same security flaw MBR [Master Boot Record] can be modified from usermode. Nevertheless, MS blocked write-access to disk sectors from userland code on VISTA after the pagefile attack, however, the first sectors of disk are still unprotected... At the end of 2007 stealth MBR rootkit was discovered by MR Team members (thanks to Tammy & MJ) and it looks like this way of affecting NT systems could be more common in near future if MBR stays unprotected."

http://www2.gmer.net/mbr/