Using latest version of ZA free Internet Security

It appears since using this I've had more intrusions than normally had over the last few years.

Once a week I do a Malware check and often find various ones in my Application Data, then I do a ComboFix clean to clear any files and folders connected. I already have my Host file set as read only, but still one gets in and although no warning flags up. I get suspected when IE8 starts to freeze etc.

My question, in the Custom Firewall Settings for the Trusted and Internet Zone there are settings for authorized program traffic through the various incomings and outgoings.

Could anyone advise the settings to help eliminate these malwares etc getting into my Docu & Settings, Apllication Data folder.