ZA Extreme comes with the ZA smartdefense feature. All software running on your system is checked against a centralised database of known good/ known bad applications. The applications are then configured accordingly. You don't have to worry about about anything on that list, just use your PC.
The most important thing to do to keep your system safe and usable is:
1) Always update your Ver. of Windows with latest fixes and patches
2) Always update your third party software with latest fixes
. Check with secunia site
if you are running any vulnerable software and update it.
3) Never believe any pop-up
(other than ZA) telling you are infected. They are fake
4. If you have not done so yet, turn ON "virtualization
" under the advance options of the ZA Extreme web protection section
. Most of the infections nowadays comes from legit website
and virtualization will stop all hidden drive-by-download attempts.